Nampt^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Nampt^tm1.1Arte
• Name: nicotinamide phosphoribosyltransferase; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:6189117
• Synonyms: Nampt^fl, Nampt^tm1Jtree
• Gene: Nampt Location: Chr12:32870334-32903368 bp, + strand Genetic Position: Chr12, 13.74 cM, cytoband B1
• Alliance: Nampt^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and a an FRT site flanked puromycin resistance gene cassette were inserted into intron 2 and a second loxP site into intron 3. The puro cassette was removed through flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:261991)

Expression

In Mice Carrying this Mutation:

114 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nampt Mutation: 91 strains or lines available

References

• Original: J:261991 Agerholm M, et al., Perturbations of NAD(+) salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle. Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E377-E395
• All: 6 reference(s)