Dpp10^m1H
Chemically induced Allele Detail

Summary

• Symbol: Dpp10^m1H
• Name: dipeptidylpeptidase 10; mutation 1, Harwell
• MGI ID: MGI:6189061
• Synonyms: Dpp10^145D
• Gene: Dpp10 Location: Chr1:123259871-124773774 bp, - strand Genetic Position: Chr1, 53.68 cM
• Alliance: Dpp10^m1H page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: An A-to-T residue in the genome results in a amino acid change from valine to aspartic acid in codon 145 in exon 5. Immunohistochemistry analysis suggests that the mutation leads to altered protein localization rather than complete loss of protein. (J:257086)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpp10 Mutation: 57 strains or lines available

References

• Original: J:257086 Zhang Y, et al., Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Dis Model Mech. 2018 Jan 29;11(1):dmm031369
• All: 1 reference(s)