Nox1^tm1.2Anrt
Targeted Allele Detail

Summary

• Symbol: Nox1^tm1.2Anrt
• Name: NADPH oxidase 1; targeted mutation 1.2, Asma Nusrat
• MGI ID: MGI:6188873
• Gene: Nox1 Location: ChrX:132987170-133038455 bp, - strand Genetic Position: ChrX, 55.69 cM
• Alliance: Nox1^tm1.2Anrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249016
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13. An FRT-flanked neo cassette with a 3' loxP site and modified exon 13 with an insertion of an in-frame lacZ gene. Flp-mediated recombination removed the neo cassette and left exon 13 floxed. Gerline-mediated cre recombination removed the loxP flanked sequences including the endogenous exon 13, creating a null allele and reporter. (J:249016)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox1 Mutation: 12 strains or lines available

References

• Original: J:249016 Hofstetter AR, et al., NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice. PLoS One. 2016;11(2):e0149864
• All: 1 reference(s)