Apoe^{em3(APOE*)Adiuj}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apoe^{em3(APOE*)Adiuj}
• Name: apolipoprotein E; endonuclease-mediated mutation 3, MODEL-AD Center
• MGI ID: MGI:6164017
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{em3(APOE*)Adiuj} page

Mutation origin

• Strain of Origin: B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj}/J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Apoe^{em3(APOE*)Adiuj} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: CRISPR/Cas9 genome editing methodologies was used to introduce R130C and R176C point mutations into human APOE protein carried by the Apoe^{tm1.1(APOE*4)Adpmc} allele. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 146 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)