Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Apoetm1.1(APOE*4)Adiuj
Name:	apolipoprotein E; targeted mutation 1.1, MODEL-AD Center
MGI ID:	MGI:5810209
Synonyms:	APOEepsilon4
Gene:	Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance:	Apoetm1.1(APOE*4)Adiuj page

Germline Transmission:	Earliest citation of germline transmission: J:323137
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion, Nucleotide substitutions   Apoetm1.1(APOE*4)Adiuj expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human APOE (348) Apoe  (MGI:88057) APOE4 isoform   Mutation details: The targeting vector contains a 3' FRT flanked neo cassette and 1.5 kb of human APOE gene sequence including exons 2, 3, 4 and a portion of the 3'UTR sequence (the APOE4 isoform) which is used to replace exons 2, 3 and most of exon 4 of the endogenous sequence. The human ApoE sequence carries a 2 nucleotide A to T substitution in intron 3. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:323137)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 36 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:	145 strains or lines available

Original:	J:323137 Foley KE, et al., The APOE (epsilon3/epsilon4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice. Front Aging Neurosci. 2022;14:838436
All:	15 reference(s)