Tg(ACTB-EGFP,-NOX1)1Jdla
Transgene Detail

Summary

• Symbol: Tg(ACTB-EGFP,-NOX1)1Jdla
• Name: transgene insertion 1, J Lambeth
• MGI ID: MGI:6159583
• Synonyms: Tg^nox1
• Transgene: Tg(ACTB-EGFP,-NOX1)1Jdla Location: unknown
• Alliance: Tg(ACTB-EGFP,-NOX1)1Jdla page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(ACTB-EGFP,-NOX1)1Jdla expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NOX1 (27035)

  Nox1	(MGI:2450016)

  conditional: expressed only after removal of floxed EGFP-STOP cassette

• Mutation details: The transgenic construct is of a CX1 promoter (consisting of a portion of the beta-actin and CMV enhancer sequences), a loxP-flanked EGFP/Stop polyA cassette and the human NOX1 cDNA, This high copy founder line (Tg1) incorporates more than 50 copies of the transgene. (J:127882)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127882 Dikalova A, et al., Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation. 2005 Oct 25;112(17):2668-76
• All: 1 reference(s)