Nrxn2^tm7.1Sud
Targeted Allele Detail

Summary

• Symbol: Nrxn2^tm7.1Sud
• Name: neurexin II; targeted mutation 7.1, Thomas C Sudhoff
• MGI ID: MGI:6157352
• Gene: Nrxn2 Location: Chr19:6468786-6583247 bp, + strand Genetic Position: Chr19, 4.65 cM
• Alliance: Nrxn2^tm7.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin resistance cassette were inserted in intron 17 of the mouse Nrxn2 gene, and an F3-flanked puromycin resistance cassette followed by a loxP site were placed in intron 18. Flp-mediated recombination removed the FRT-flanked neo cassette. The puromycin cassette was also removed. (J:346434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrxn2 Mutation: 91 strains or lines available

References

• Original: J:242553 Chen LY, et al., Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. Neuron. 2017 May 03;94(3):611-625.e4
• All: 4 reference(s)