Psmc5^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Psmc5^tm1.1Itl
• Name: protease (prosome, macropain) 26S subunit, ATPase 5; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:6155608
• Synonyms: Rpt6^S120D
• Gene: Psmc5 Location: Chr11:106147011-106153938 bp, + strand Genetic Position: Chr11, 68.89 cM, cytoband E1
• Alliance: Psmc5^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260973
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An FRT-flanked neomycin resistance cassette was inserted upstream of exon 4. Exon 5 was modified with a nucleotide substitution (AGC to GAC) resulting in the amino acid substitution of aspartic acid for serine at position 120 (S120D). This modification creates a phospho-mimetic version. Flp-mediated recombination removed the selection cassette. (J:260973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc5 Mutation: 31 strains or lines available

References

• Original: J:260973 Gonzales FR, et al., Proteasome phosphorylation regulates cocaine-induced sensitization. Mol Cell Neurosci. 2018 Apr;88:62-69
• All: 1 reference(s)