Mal^{em1(IMPC)Wtsi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mal^{em1(IMPC)Wtsi}
• Name: myelin and lymphocyte protein, T cell differentiation protein; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6153486
• Gene: Mal Location: Chr2:127475146-127498615 bp, - strand Genetic Position: Chr2, 62.06 cM
• Alliance: Mal^{em1(IMPC)Wtsi} page
• IMPC: Mal gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Wellcome Sanger Institute using Cas9 and guides with spacer sequences ATGGGTATGATTCAAAGGCC, CCCTAAGTCTACCAGCTTAA, GGGCTGGGTGACCTTCTACT, and TTCCCTGCAACCCGCGCATC that targeted exon(s) ENSMUSE00000168888.2. This resulted in deletion(s) of 357 bp (location: Chr2:127480425-127480781; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mal Mutation: 21 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 2 reference(s)