Gpr37l1^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Gpr37l1^{tm1d(EUCOMM)Wtsi}
• Name: G protein-coupled receptor 37-like 1; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:6150820
• Synonyms: GPR37L1^KO
• Gene: Gpr37l1 Location: Chr1:135087988-135095419 bp, - strand Genetic Position: Chr1, 58.25 cM
• Alliance: Gpr37l1^{tm1d(EUCOMM)Wtsi} page
• IMPC: Gpr37l1 gene page

Mutation origin

• Mutant Cell Line: EPD0486_2_B09
• Germline Transmission: Earliest citation of germline transmission: J:260359
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 135087743 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 135089893. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression resulted in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:260359)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr37l1 Mutation: 32 strains or lines available

References

• Original: J:260359 Coleman JLJ, et al., Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biol Sex Differ. 2018 Apr 6;9(1):14
• All: 3 reference(s)