Htr2b^tm2Lum
Targeted Allele Detail

Summary

• Symbol: Htr2b^tm2Lum
• Name: 5-hydroxytryptamine (serotonin) receptor 2B; targeted mutation 2, Luc Maroteaux
• MGI ID: MGI:6148024
• Synonyms: Htr2b^lox
• Gene: Htr2b Location: Chr1:86026748-86039692 bp, - strand Genetic Position: Chr1, 43.94 cM
• Alliance: Htr2b^tm2Lum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the 5'UTR (2nd exon) and a neomycin-resistance (NEO) cassette flanked by two loxP sites was inserted in the ClaI site of the second intron. (J:258484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr2b Mutation: 26 strains or lines available

References

• Original: J:258484 Belmer A, et al., Positive regulation of raphe serotonin neurons by serotonin 2B receptors. Neuropsychopharmacology. 2018 Jun;43(7):1623-1632
• All: 4 reference(s)