Tg(CRY2*A260T)25Ljp
Transgene Detail
|
Symbol: |
Tg(CRY2*A260T)25Ljp |
Name: |
transgene insertion 25, Louis Ptacek |
MGI ID: |
MGI:6121044 |
Synonyms: |
hCRY2-A260T |
Transgene: |
Tg(CRY2*A260T)25Ljp Location: unknown
|
Alliance: |
Tg(CRY2*A260T)25Ljp page
|
|
|
Transgene Type: |
|
Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(CRY2*A260T)25Ljp expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CRY2 (1408) |
|
Expresses an A260T mutation |
|
|
|
Mutation details: The transgenic construct contains human BAC RP11-1084E2, encoding full-length CRY2 and incorporating an A260T (amino acid)/GAACGCCA to GAACACCA (nucleotide) mutation. Founder line 25 carries 10 copies of the transgene. The A260T missense mutation was identified in one family affected with Familial Advanced Sleep Phase (FASP). The mutation is located in the phosphate loop of the flavin adenine dinucleotide (FAD) binding domain.
(J:257412)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:257412 Hirano A, et al., A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife. 2016 Aug 16;5:e16695 |
All: |
1 reference(s) |
|