Rr46^tm1.1Tshir
Targeted Allele Detail

Summary

• Symbol: Rr46^tm1.1Tshir
• Name: regulatory region 46; targeted mutation 1.1, Toshihiko Shiroishi
• MGI ID: MGI:6117322
• Synonyms: Macs1^-
• Gene: Rr46 Location: Chr5:29416520-29418073 bp Genetic Position: Chr5, Syntenic
• Alliance: Rr46^tm1.1Tshir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244162
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Rr46^tm1.1Tshir involves 1 genes/genome features (Rnf32) View all
• Mutation details: A floxed neomycin resistance gene cassette replaced a 1,554-bp fragment (chr5: 29,211,522-29,213,075 mm10) encompassing the Shh endoderm enhancer MACS1. Cre-mediated recombination removed the selection cassette. (J:244162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr46 Mutation: 0 strains or lines available

References

• Original: J:244162 Sagai T, et al., Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder. Nat Commun. 2017 Feb 03;8:14300
• All: 1 reference(s)