Lyz2^{tm1(cre/ERT2)Grtn}
Targeted Allele Detail

Summary

• Symbol: Lyz2^{tm1(cre/ERT2)Grtn}
• Name: lysozyme 2; targeted mutation 1, Florian R Greten
• MGI ID: MGI:6114757
• Synonyms: LysM-Cre ER^T2
• Gene: Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
• Alliance: Lyz2^{tm1(cre/ERT2)Grtn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252269
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Lyz2^{tm1(cre/ERT2)Grtn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lyz2 (MGI:96897)

• Mutation details: A targeting construct was generated by replacing Exon 1 of Lyz2 gene with a cre/ERT2, and an FRT-flanked neomycin/kanamycin cassette to drive inducible recombinase activity in myeloid cells. (J:252269)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz2 (mouse) Summary of all recombinase alleles driven by Lyz2. Alliance mouse Lyz2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lyz2 Mutation: 41 strains or lines available

References

• Original: J:252269 Canli O, et al., Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis. Cancer Cell. 2017 Dec 11;32(6):869-883.e5
• All: 9 reference(s)