Tifab^tm1.1Dsta
Targeted Allele Detail

Summary

• Symbol: Tifab^tm1.1Dsta
• Name: TRAF-interacting protein with forkhead-associated domain, family member B; targeted mutation 1.1, Daniel T Starczynowski
• MGI ID: MGI:5911664
• Gene: Tifab Location: Chr13:56321517-56326698 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Tifab^tm1.1Dsta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229024
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 which encodes the protein coding region was replaced with a beta- galactosidase cassette and a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. Immunoblot analysis confirmed the absence of protein expression in bone marrow lysates from homozygous mice. (J:229024)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tifab Mutation: 19 strains or lines available

References

• Original: J:229024 Varney ME, et al., Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J Exp Med. 2015 Oct 19;212(11):1967-85
• All: 2 reference(s)