Kat14^{tm1d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Kat14^{tm1d(KOMP)Wtsi}
• Name: lysine acetyltransferase 14; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5910764
• Synonyms: Csrp2bp^Ex
• Gene: Kat14 Location: Chr2:144210952-144249595 bp, + strand Genetic Position: Chr2, 71.01 cM
• Alliance: Kat14^{tm1d(KOMP)Wtsi} page
• IMPC: Kat14 gene page

Mutation origin

• Mutant Cell Line: EPD0025_4_B07
• Germline Transmission: Earliest citation of germline transmission: J:236024
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 144217323 of Chromosome 2 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon at position 144218113. The critical exon 3 is thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). (J:236024)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat14 Mutation: 76 strains or lines available

References

• Original: J:236024 Shen AL, et al., Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. PLoS One. 2016;11(6):e0157577
• All: 1 reference(s)