Klf14^em1Cgw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klf14^em1Cgw
• Name: Kruppel-like transcription factor 14; endonuclease-mediated mutation 1, Chuangui Wang
• MGI ID: MGI:5907263
• Gene: Klf14 Location: Chr6:30932956-30935925 bp, - strand Genetic Position: Chr6, 12.54 cM
• Alliance: Klf14^em1Cgw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An 8 nucleotide deletion was created using TALEN mediated targeting. This deletion creates a frameshift mutation at the tenth amino acid resulting in premature termination. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts from homozygous mice. (J:227200)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Klf14^em1Cgw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf14 Mutation: 22 strains or lines available

References

• Original: J:227200 Fan G, et al., Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun. 2015;6:8450
• All: 2 reference(s)