Tg(CAG-Nos1ap)112Achak
Transgene Detail

Summary

• Symbol: Tg(CAG-Nos1ap)112Achak
• Name: transgene insertion 112, Aravinda Chakravarti
• MGI ID: MGI:5903441
• Synonyms: Nos1ap^Tg
• Transgene: Tg(CAG-Nos1ap)112Achak Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Tg(CAG-Nos1ap)112Achak page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-Nos1ap)112Achak expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nos1ap (MGI:1917979)	conditional expression

• Mutation details: The CAG promoter drives the expression of floxed lacZ followed by three polyadenylation (pA) signals. Following this is the Nos1ap open reading frame (ORF, NM_001109985) including start and stop codons; this is then followed by an IRES-puromycin-pA cassette. In the presence of cre recombinase, the floxed lacZ-polyA cassette is deleted, leaving Nos1ap under the control of the strong constitutive enhancer-promoter element. This leads to Nos1ap overexpression in the tissues in which cre recombinase is expressed. Lines 112, 314 and 333 were generated. (J:232078)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:232078 Auer DR, et al., Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse. Biotechnol Lett. 2014 Jun;36(6):1179-85
• All: 1 reference(s)