Il33^{tm2.1(IL33)Arte}
Targeted Allele Detail

Summary

• Symbol: Il33^{tm2.1(IL33)Arte}
• Name: interleukin 33; targeted mutation 2.1, TaconicArtemis
• MGI ID: MGI:5829418
• Synonyms: hIL-33⁺/mIL33^-
• Gene: Il33 Location: Chr19:29902514-29938118 bp, + strand Genetic Position: Chr19, 24.56 cM, cytoband C2
• Alliance: Il33^{tm2.1(IL33)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227003
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Il33^{tm2.1(IL33)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL33 (90865)

  Il33	(MGI:1924375)

• Mutation details: The coding sequence was replaced with the corresponding human genomic sequence. Flp-mediated recombination removed the FRT-flanked puromycin cassette inserted downstream of exon 1. (J:227003)

Generation of Il33^{tm2.1(IL33)Arte} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il33 Mutation: 30 strains or lines available

References

• Original: J:227003 Cohen ES, et al., Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation. Nat Commun. 2015;6:8327
• All: 2 reference(s)