Wwox^tm2.1Lhsu
Targeted Allele Detail

Summary

• Symbol: Wwox^tm2.1Lhsu
• Name: WW domain-containing oxidoreductase; targeted mutation 2.1, Li-Jin Hsu
• MGI ID: MGI:5819378
• Gene: Wwox Location: Chr8:115166395-116079447 bp, + strand Genetic Position: Chr8, 60.99 cM, cytoband E1
• Alliance: Wwox^tm2.1Lhsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238174
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a further loxP site were inserted downstream of exon 4. Exons 2, 3 and 4 and the neo cassette were removed through subsequent cre-mediated recombination, creating a null allele. (J:238174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwox Mutation: 59 strains or lines available

References

• Original: J:238174 Chang JY, et al., Trafficking protein particle complex 6A delta (TRAPPC6ADelta) is an extracellular plaque-forming protein in the brain. Oncotarget. 2015 Feb 28;6(6):3578-89
• All: 3 reference(s)