Tg(Thy1-MBP*/EGFP)CWevn
Transgene Detail

Summary

• Symbol: Tg(Thy1-MBP*/EGFP)CWevn
• Name: transgene insertion C,William Van Nostrand
• MGI ID: MGI:5806474
• Synonyms: Tg-MBP1-EGFP
• Transgene: Tg(Thy1-MBP*/EGFP)CWevn Location: unknown
• Alliance: Tg(Thy1-MBP*/EGFP)CWevn page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Thy1-MBP*/EGFP)CWevn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MBP (4155)

  Mbp	(MGI:96925)

  A human MBP N-terminal fragment containing amino acids 1-64 fused to EGFP

• Mutation details: A human myelin basic protein (MBP) N-terminal fragment containing amino acids 1-64 and fused to EGFP at its C-terminus was subcloned into exon 2 of the mouse Thy1 expression cassette. The Thy1 cassette was altered to remove exon 3 and its flanking introns, limiting expression to neural cells. (J:219504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:219504 Ou-Yang MH, et al., N-terminal region of myelin basic protein reduces fibrillar amyloid-beta deposition in Tg-5xFAD mice. Neurobiol Aging. 2015 Feb;36(2):801-11
• All: 1 reference(s)