Malt1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Malt1^tm1.1Geno
• Name: MALT1 paracaspase; targeted mutation 1.1, Genoway
• MGI ID: MGI:5805283
• Synonyms: Malt1^PD
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of a modified exon 12, in which nucleotide substitutions (TGT to GCC) results in the amino acid substitution of alanine for cysteine at position 472 (C472A). This mutation inactivates the protease activity. Flp-mediated recombination removed the selection cassette and left the modified exon 12 is floxed. (J:235331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:235331 Yu JW, et al., MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses. PLoS One. 2015;10(5):e0127083
• All: 3 reference(s)