Klb^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Klb^tm1Smoc
• Name: klotho beta; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:5796176
• Synonyms: Klb^tm1Srcmo
• Gene: Klb Location: Chr5:65505657-65541350 bp, + strand Genetic Position: Chr5, 33.64 cM
• Alliance: Klb^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234319
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. (J:234319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klb Mutation: 60 strains or lines available

References

• Original: J:234319 Lin Z, et al., Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation. 2015 May 26;131(21):1861-71
• All: 5 reference(s)