Tg(CMV-AR*113Q)FMonk
Transgene Detail

Summary

• Symbol: Tg(CMV-AR*113Q)FMonk
• Name: transgene insertion F, Douglas Monks
• MGI ID: MGI:5790708
• Synonyms: CMV-stop-AR113Q
• Transgene: Tg(CMV-AR*113Q)FMonk Location: unknown
• Alliance: Tg(CMV-AR*113Q)FMonk page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-AR*113Q)FMonk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

  contains a polyglutamine expansion with 113 repeats.

• Mutation details: The transgenic construct consists of CMV promoter sequences, a loxP-flanked neomycin-STOP cassette and a full length human androgen receptor (AR) cDNA containing a polyglutamine expansion with 113 repeats. (J:221668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:221668 Ramzan F, et al., Distinct Etiological Roles for Myocytes and Motor Neurons in a Mouse Model of Kennedy's Disease/Spinobulbar Muscular Atrophy. J Neurosci. 2015 Apr 22;35(16):6444-51
• All: 1 reference(s)