Gabra5^tm2.2Uru
Targeted Allele Detail

Summary

• Symbol: Gabra5^tm2.2Uru
• Name: gamma-aminobutyric acid type A receptor subunit alpha 5; targeted mutation 2.2, Uwe Rudolph
• MGI ID: MGI:5788283
• Synonyms: gl-alpha5-KO
• Gene: Gabra5 Location: Chr7:57057420-57159807 bp, - strand Genetic Position: Chr7, 33.52 cM
• Alliance: Gabra5^tm2.2Uru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were flanked by loxP sites and removed by cre-mediated recombination. The selectable markers were removed in vitro. (J:224380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra5 Mutation: 32 strains or lines available

References

• Original: J:224380 Rodgers FC, et al., Etomidate Impairs Long-Term Potentiation In Vitro by Targeting alpha5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. J Neurosci. 2015 Jul 1;35(26):9707-16
• All: 7 reference(s)