Gskip^tm1.1Ekn
Targeted Allele Detail

Summary

• Symbol: Gskip^tm1.1Ekn
• Name: GSK3B interacting protein; targeted mutation 1.1, Enno Klussmann
• MGI ID: MGI:5784740
• Synonyms: Gskip^fl, Gskip^flx
• Gene: Gskip Location: Chr12:105651611-105669317 bp, + strand Genetic Position: Chr12, 55.92 cM
• Alliance: Gskip^tm1.1Ekn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228948
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:228948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gskip Mutation: 18 strains or lines available

References

• Original: J:228948 Deak VA, et al., The A-kinase Anchoring Protein GSKIP Regulates GSK3beta Activity and Controls Palatal Shelf Fusion in Mice. J Biol Chem. 2016 Jan 8;291(2):681-90
• All: 1 reference(s)