Aldh1b1^tm1Vvas
Targeted Allele Detail

Summary

• Symbol: Aldh1b1^tm1Vvas
• Name: aldehyde dehydrogenase 1 family, member B1; targeted mutation 1, Vasilis Vasiliou
• MGI ID: MGI:5779307
• Gene: Aldh1b1 Location: Chr4:45799022-45804604 bp, + strand Genetic Position: Chr4, 24.35 cM, cytoband B2
• Alliance: Aldh1b1^tm1Vvas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228677
• Parent Cell Line: EC7.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the coding sequence in exon 2. Western blot analysis confirmed the absence of protein expression in the liver, small intestine and colon. (J:228677)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1b1 Mutation: 34 strains or lines available

References

• Original: J:228677 Singh S, et al., ALDH1B1 links alcohol consumption and diabetes. Biochem Biophys Res Commun. 2015 Aug 7;463(4):768-73
• All: 1 reference(s)