Abcb10^tm1.1Tafu
Targeted Allele Detail

Summary

• Symbol: Abcb10^tm1.1Tafu
• Name: ATP-binding cassette, sub-family B member 10; targeted mutation 1.1, Tatsuhiko Furukawa
• MGI ID: MGI:5708653
• Synonyms: Abcb10^F
• Gene: Abcb10 Location: Chr8:124679198-124709861 bp, - strand Genetic Position: Chr8, 72.31 cM
• Alliance: Abcb10^tm1.1Tafu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223428
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-FRT and a loxP-pMC1 neo-FRT-loxP were inserted upstream and downstream of exon 3, respectively. Flp-mediated recombination removed the neo resistance cassette, leaving exon 3 flanked by loxP sites. (J:223428)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcb10 Mutation: 42 strains or lines available

References

• Original: J:223428 Yamamoto M, et al., Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. Mol Cell Biol. 2014 Mar;34(6):1077-84
• All: 1 reference(s)