Map4k4^tm1Tht
Targeted Allele Detail

Summary

• Symbol: Map4k4^tm1Tht
• Name: mitogen-activated protein kinase kinase kinase kinase 4; targeted mutation 1, Tse-Hua Tan
• MGI ID: MGI:5707482
• Synonyms: HGK^f, HGK^flox
• Gene: Map4k4 Location: Chr1:39940073-40065470 bp, + strand Genetic Position: Chr1, 18.53 cM, cytoband B
• Alliance: Map4k4^tm1Tht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224579
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. (J:224579)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k4 Mutation: 104 strains or lines available

References

• Original: J:224579 Chuang HC, et al., HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat Commun. 2014;5:4602
• All: 2 reference(s)