Mirc34^tm1.1Mkss
Targeted Allele Detail

Summary

• Symbol: Mirc34^tm1.1Mkss
• Name: microRNA cluster 34, including Mir449a through Mir449c; targeted mutation 1.1, Michael Kessel
• MGI ID: MGI:5705617
• Synonyms: mir-449^-
• Gene: Mirc34 Location: Chr13:113172517-113174158 bp Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mirc34^tm1.1Mkss involves 3 genes/genome features (Mir449c, Mir449b, Mir449a) View all
• Mutation details: A loxP site was inserted upstream of Mir449c. A FRT flanked neomycin resistance cassette and a 3' loxP site were inserted downstream of Mir449a. Cre-mediated recombination removed Mir449a, Mir449b, Mir449c and the selection cassette. (J:223064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc34 Mutation: 1 strain or line available

References

• Original: J:223064 Song R, et al., miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature. 2014 Jun 5;510(7503):115-20
• All: 4 reference(s)