Mirc34 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc34
• Name
  microRNA cluster 34, including Mir449a through Mir449c

• Feature Type
  complex/cluster/region
• IDs
  MGI:5469875
• Cluster Members
  Mir449c, Mir449b, Mir449a (3 members)

Location &
Maps

• Sequence Map
  Chr13:113172517-113174158 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, Syntenic

Strain
Comparison

• SNPs within 2kb
  50 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 4 genetic backgrounds
  28 phenotypes from multigenic genotypes
  13 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  1
• Targeted
  6
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous for a knock-out allele exhibit no abnormal phenotype. Mice homozygous for a null allele of all Mir34 and Mir449 microRNAs exhibit postnatal lethality, premature death, reduced body weight, blepharoptosis, microphthalmia, hunched posture, abnormal locomotor coordination, decreased thermal nociceptive threshold, and altered number of sub-population of motor synergy encoder neurons.

Other Database
Links

miRBase

MI0001649, MI0004645, MI0005547

References

• Summaries
  All 15

  Phenotypes 13
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:341749 Chen TH, et al., MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice. Mol Ther Nucleic Acids. 2023 Jun 13;32:144-160

Mirc34 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir449c, microRNA 449c	miRNA gene	Chr13:113172517-113172625 (+)
Mir449b, microRNA 449b	miRNA gene	Chr13:113173953-113174032 (+)
Mir449a, microRNA 449a	miRNA gene	Chr13:113174068-113174158 (+)