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Dp(16Igsf5-Zbtb21)6TybEmcf
Targeted Allele Detail
Summary
Symbol: Dp(16Igsf5-Zbtb21)6TybEmcf
Name: duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 6
MGI ID: MGI:5703808
Synonyms: Dp(16)6TybEmcf, Dp6Tyb
Gene: Dp(16Igsf5-Zbtb21)6TybEmcf  Location: unknown  Genetic Position: Chr16, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227899
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted
Mutations:    Duplication, Insertion
  Dp(16Igsf5-Zbtb21)6TybEmcf involves 25 genes/genome features (Gm24777, Gm41514, Gm41511 ...) View all
 
Mutation details: MICER vectors MHPN235b18 (16:96327324-16:96331804 Mb) located between B3galt5 and Igsf5 and MHPN352i16 (16:97977263-16:97982380 Mb) were used to insert loxP sites proximal to Igsf5 and distal to Zbtb21. Cre-mediated recombination duplicated the sequence floxed by loxP sites. (J:227899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dp(16Igsf5-Zbtb21)6TybEmcf Mutation:  2 strains or lines available
References
Original:  J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory