Vapb^tm1.1Tsud
Targeted Allele Detail

Summary

• Symbol: Vapb^tm1.1Tsud
• Name: vesicle-associated membrane protein, associated protein B and C; targeted mutation 1.1, Hiroshi Tsuda
• MGI ID: MGI:5697413
• Synonyms: Vapb^P56S
• Gene: Vapb Location: Chr2:173579378-173626132 bp, + strand Genetic Position: Chr2, 97.37 cM, cytoband H3
• Alliance: Vapb^tm1.1Tsud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226459
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector is designed to replace exon 2 of the gene with the an altered exon 2 carrying a P56S (proline to serine) missense mutation and a loxP-flanked PGK-neo cassette. Cre-mediated recombination removed the floxed neo cassette. (J:226459)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vapb Mutation: 28 strains or lines available

References

• Original: J:226459 Larroquette F, et al., Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Hum Mol Genet. 2015 Nov 15;24(22):6515-29
• All: 1 reference(s)