Upk3b^tm1.1Akis
Targeted Allele Detail

Summary

• Symbol: Upk3b^tm1.1Akis
• Name: uroplakin 3B; targeted mutation 1.1, Andreas Kispert
• MGI ID: MGI:5695209
• Synonyms: Upk3b^creERT2
• Gene: Upk3b Location: Chr5:136067350-136073847 bp, + strand Genetic Position: Chr5, 75.7 cM
• Alliance: Upk3b^tm1.1Akis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225159
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a tamoxifen-inducible cre recombinase gene (cre/ERT2) and floxed neomycin resistnace cassette. Cre-mediated recombination removed the selection cassette. In situ hybridization fails to detect cre expression. Semi-quantitative RT-PCR confirmed the absence of transcript expression in the heart at E12.5. (J:225159)

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upk3b Mutation: 13 strains or lines available

References

• Original: J:225159 Rudat C, et al., Upk3b is dispensable for development and integrity of urothelium and mesothelium. PLoS One. 2014;9(11):e112112
• All: 1 reference(s)