Itch^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itch^m1Btlr
• Name: itchy, E3 ubiquitin protein ligase; mutation 1, Bruce Beutler
• MGI ID: MGI:5691957
• Synonyms: scratch
• Gene: Itch Location: Chr2:154975429-155068775 bp, + strand Genetic Position: Chr2, 76.94 cM
• Alliance: Itch^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition at base pair 155,172,561 (v38) on chromosome 2, or base pair 39,183 in the GenBank genomic region NC_000068, corresponding to residue 520 in the mRNA sequence NM_008395 (variant 1) within exon 5 of 25 total exons and residue 722 in the mRNA sequence NM_001243712 (variant 2) within exon 6 of 26 total exons. The mutation results in a leucine (L) to serine (S) substitution at position 106 (L106S) in both variants of the protein. (J:225270)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itch Mutation: 91 strains or lines available

References

• Original: J:225270 SoRelle J, et al., Mutagenetix entry for scratch. MGI Direct Data Submission. 2015
• All: 1 reference(s)