Elovl6^tm1Jdh
Targeted Allele Detail

Summary

• Symbol: Elovl6^tm1Jdh
• Name: ELOVL fatty acid elongase 6; targeted mutation 1, Jay D Horton
• MGI ID: MGI:5691743
• Gene: Elovl6 Location: Chr3:129326035-129432144 bp, + strand Genetic Position: Chr3, 58.05 cM
• Alliance: Elovl6^tm1Jdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217185
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaces a 1.2 kB genomic fragment containing promoter sequences, exon 1 and exon 2. Northern blot analysis using liver RNA showed that no detectable transcript is present in homozyogus mice. (J:217185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elovl6 Mutation: 253 strains or lines available

References

• Original: J:217185 Moon YA, et al., Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance. J Lipid Res. 2014 Dec;55(12):2597-605
• All: 1 reference(s)