Malt1^tm1.1Math
Targeted Allele Detail

Summary

• Symbol: Malt1^tm1.1Math
• Name: MALT1 paracaspase; targeted mutation 1.1, Margot Thome
• MGI ID: MGI:5662447
• Synonyms: Malt1^ki
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^tm1.1Math page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216675
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A TGTCGG to GCCAGA mutation at nucleotides 168-173 of exon 11 encoding a C472A substitution was introduced and an FRT flanked neo cassette was inserted in intron 10 via homologous recombination. Flp mediated recombination removed the neo cassette. Immunoblot analysis indicates expression of the mutant protein at levels similar to wild-type protein. The C472A mutation produces a catalytically inactive protein that fails to cleave multiple substrates (Bcl-10, Regnase-1, RelB, and CYLD). (J:216675)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:216675 Jaworski M, et al., Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. EMBO J. 2014 Dec 1;33(23):2765-81
• All: 2 reference(s)