Casp3^m1H
Chemically induced Allele Detail

Summary

• Symbol: Casp3^m1H
• Name: caspase 3; mutation 1, MRC Mammalian Genetics Unit, Harwell
• MGI ID: MGI:5646608
• Synonyms: Casp3^I216F, Casp3^m1Bha
• Gene: Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
• Alliance: Casp3^m1H page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a nucleotide substitution in codon 216 that introduces an MboII restriction site. This results in an Isoleucine to Phenylalanine change at amino acid 216 of the encoded protein. (J:169366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Casp3 Mutation: 31 strains or lines available

Notes

The original mutation was identified from the MRC-Harwell's paired DNA-sperm library of ENU-mutagenised males.

References

• Original: J:169366 MouseBook^TM, Information obtained from MouseBook^TM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished. 2005-2013
• All: 1 reference(s)