Grhl2^tm1Ksot
Targeted Allele Detail

Summary

• Symbol: Grhl2^tm1Ksot
• Name: grainyhead like transcription factor 2; targeted mutation 1, Kai M Schmidt-Ott
• MGI ID: MGI:5646286
• Gene: Grhl2 Location: Chr15:37233280-37363813 bp, + strand Genetic Position: Chr15, 14.84 cM, cytoband C
• Alliance: Grhl2^tm1Ksot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220468
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Neomycin cassette flanked by two frt sites in intron 3 and loxP-flanked exon 4 were inserted via homologous recombination. Flp-mediated recombination removed the neomycin cassette. (J:220468)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grhl2 Mutation: 42 strains or lines available

References

• Original: J:220468 Walentin K, et al., A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15;142(6):1125-36
• All: 4 reference(s)