Ndrg2^tm1.1Hori
Targeted Allele Detail

Summary

• Symbol: Ndrg2^tm1.1Hori
• Name: N-myc downstream regulated gene 2; targeted mutation 1.1, Osamu Hori
• MGI ID: MGI:5636684
• Synonyms: Ndrg2^-
• Gene: Ndrg2 Location: Chr14:52142728-52151461 bp, - strand Genetic Position: Chr14, 26.72 cM
• Alliance: Ndrg2^tm1.1Hori page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214686
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette along with exons 3 and 4. RT-PCR and Western blot analysis confirmed absence of mRNA and protein expression in the brain, liver, and heart from homozygous mutant mice. (J:214686)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndrg2 Mutation: 26 strains or lines available

References

• Original: J:214686 Takarada-Iemata M, et al., Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. J Neurochem. 2014 Aug;130(3):374-87
• All: 4 reference(s)