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Targeted Allele Detail
Symbol: Fosbtm3.1Yun
Name: FBJ osteosarcoma oncogene B; targeted mutation 3.1, Yusaku Nakabeppu
MGI ID: MGI:5634958
Synonyms: fosBF
Gene: Fosb  Location: Chr7:19036621-19043970 bp, - strand  Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
Alliance: Fosbtm3.1Yun page
Germline Transmission:  Earliest citation of germline transmission: J:211298
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Nucleotide substitutions
Mutation detailsThree bases (GAGGTGAGA->GAAGTTCGA) in the alternative splicing donor site and two bases (AGTGAA->TCTGAA) in the splice acceptor site were modified via homologous recombination to prevent expression of the long transcript while retaining expression of the shorter transcript. A floxed neo cassette was also inserted in intron 3. Cre mediated recombination removed the neo cassette. This allele lacks expression of the deltaFosb isoform. (J:220449)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fosb Mutation:  16 strains or lines available
Original:  J:220449 Ohnishi YN, et al., Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008 Nov;19(11):4717-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory