Syne2^tm1Chen
Targeted Allele Detail

Summary

• Symbol: Syne2^tm1Chen
• Name: spectrin repeat containing, nuclear envelope 2; targeted mutation 1, Ju Chen
• MGI ID: MGI:5618415
• Gene: Syne2 Location: Chr12:75865092-76157702 bp, + strand Genetic Position: Chr12, 33.11 cM
• Alliance: Syne2^tm1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211007
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion A single exon was flanked by loxP sites with Frt-neo-Frt cassette before the second loxP sequence. (J:211007)

Generation of the Syne2^tm1Chen allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne2 Mutation: 297 strains or lines available

References

• Original: J:211007 Banerjee I, et al., Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet. 2014 Feb;10(2):e1004114
• All: 1 reference(s)