Hepacamtm1.1Tjj
Targeted Allele Detail
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Symbol: |
Hepacamtm1.1Tjj |
Name: |
hepatocyte cell adhesion molecule; targeted mutation 1.1, Thomas J Jentsch |
MGI ID: |
MGI:5618261 |
Synonyms: |
Glialcamdn |
Gene: |
Hepacam Location: Chr9:37278652-37297868 bp, + strand Genetic Position: Chr9, 20.76 cM
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Alliance: |
Hepacamtm1.1Tjj page
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Germline Transmission: |
Earliest citation of germline transmission:
J:210308
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Conditional ready, Dominant negative) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A loxP site and FRT flanked neo cassette were inserted into intron 1, a G98S mutation (GG to TC) was introduced in exon 2, and an F3 flanked puro cassette and loxP site were inserted into intron 4 via homologous recombination. Flp mediated recombination removed the selection cassettes.
(J:210308)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hepacam Mutation: |
22 strains or lines available
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Original: |
J:210308 Hoegg-Beiler MB, et al., Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction. Nat Commun. 2014;5:3475 |
All: |
1 reference(s) |
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