Col1a1^{tm2(tetO-IDH2*R140Q)Ppp}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm2(tetO-IDH2*R140Q)Ppp}
• Name: collagen, type I, alpha 1; targeted mutation 2, Pier Paolo Pandolfi
• MGI ID: MGI:5617498
• Synonyms: IDH2^R140Q
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm2(tetO-IDH2*R140Q)Ppp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210097
• Parent Cell Line: C2 (Jaenisch) (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm2(tetO-IDH2*R140Q)Ppp} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Idh2

• Mutation details: A cassette with a tetracycline response element driving expression of IDH2 with an R140Q mutation was inserted into the locus. (J:210097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 160 strains or lines available

Notes

C2 (Jaenisch) ES cells are derived from ES cell line v6.5.

References

• Original: J:210097 Kats LM, et al., Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance. Cell Stem Cell. 2014 Mar 6;14(3):329-41
• All: 1 reference(s)