Rr36^tm1.1Krum
Targeted Allele Detail

Summary

• Symbol: Rr36^tm1.1Krum
• Name: regulatory region 36; targeted mutation 1.1, Robb Krumlauf
• MGI ID: MGI:5617037
• Synonyms: DE^-, DE-RARE^delta
• Gene: Rr36 Location: Chr11:96201561-96201577 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr36^tm1.1Krum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208763
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The DE-retinoic acid response element, located 3' of Hoxb5, was replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. RT-PCR analysis indicates significant down regulation of expression of Hoxb1, Hoxb5 and Hoxb6 in the hindbrain and spinal cord from homozygous mice. (J:208763)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr36 Mutation: 0 strains or lines available

References

• Original: J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
• All: 3 reference(s)