Rr36tm1.1Krum
Targeted Allele Detail
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Symbol: |
Rr36tm1.1Krum |
Name: |
regulatory region 36; targeted mutation 1.1, Robb Krumlauf |
MGI ID: |
MGI:5617037 |
Synonyms: |
DE-, DE-RAREdelta |
Gene: |
Rr36 Location: Chr11:96201561-96201577 bp Genetic Position: Chr11, Syntenic
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Alliance: |
Rr36tm1.1Krum page
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Germline Transmission: |
Earliest citation of germline transmission:
J:208763
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Modified regulatory region) |
Mutations: |
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Insertion, Intergenic deletion
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Mutation details: The DE-retinoic acid response element, located 3' of Hoxb5, was replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. RT-PCR analysis indicates significant down regulation of expression of Hoxb1, Hoxb5 and Hoxb6 in the hindbrain and spinal cord from homozygous mice.
(J:208763)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rr36 Mutation: |
0 strains or lines available
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Original: |
J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44 |
All: |
3 reference(s) |
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