Tyr^m5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tyr^m5Btlr
• Name: tyrosinase; mutation 5, Bruce Beutler
• MGI ID: MGI:5607743
• Synonyms: rufus
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^m5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a G to T transversion at base pair 87,492,706 (v38) on chromosome 7 or base pair 737 in the GenBank genomic region NC_000073, which corresponds to nucleotide 706 in the mRNA sequence NM_011661 within exon 5 of 5 total exons. The mutation results in a leucine (L) to phenylalanine (F) substitution at amino acid position 215 (L215F) of the protein. (J:216050)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 375 strains or lines available

References

• Original: J:216050 Daniel C, et al., Mutagenetix entry for rufus. Updated on December 18, 2014. MGI Direct Data Submission. 2014
• All: 1 reference(s)