Zfp318^tm1.1Jhws
Targeted Allele Detail

Summary

• Symbol: Zfp318^tm1.1Jhws
• Name: zinc finger protein 318; targeted mutation 1.1, John Weis
• MGI ID: MGI:5606279
• Synonyms: Zfp318^Fl
• Gene: Zfp318 Location: Chr17:46694657-46731846 bp, + strand Genetic Position: Chr17, 22.9 cM, cytoband C
• Alliance: Zfp318^tm1.1Jhws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215815
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of the promoter, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 2 of the gene. FLP mediated recombination removed the FRT-flanked neo cassette. (J:215815)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp318 Mutation: 80 strains or lines available

References

• Original: J:215815 Pioli PD, et al., Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus. J Immunol. 2014 Sep 1;193(5):2546-53
• All: 1 reference(s)