S1pr2^tm1.1Toka
Targeted Allele Detail

Summary

• Symbol: S1pr2^tm1.1Toka
• Name: sphingosine-1-phosphate receptor 2; targeted mutation 1.1, Takaharu Okada
• MGI ID: MGI:5605543
• Synonyms: S1pr2^V, S1pr2^Venus
• Gene: S1pr2 Location: Chr9:20877248-20888089 bp, - strand Genetic Position: Chr9, 7.68 cM
• Alliance: S1pr2^tm1.1Toka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 498 bp of S1pr2 protein coding region was replaced with a yellow fluorescent protein (Venus) gene. A loxP-flanked PGK-Neo cassette that was inserted before exon 2 was removed via Cre-mediated recombination. (J:214445)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr2 Mutation: 46 strains or lines available

References

• Original: J:214445 Moriyama S, et al., Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014 Jun 30;211(7):1297-305
• All: 4 reference(s)