Ticam2^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ticam2^M1Btlr
• Name: TIR domain containing adaptor molecule 2; mutation 1, Bruce Beutler
• MGI ID: MGI:5604364
• Synonyms: Branch
• Gene: Ticam2 Location: Chr18:46691298-46707600 bp, - strand Genetic Position: Chr18, 24.65 cM
• Alliance: Ticam2^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The Branch mutation is an A-to-T transversion at base pair 46,560,651 (v38) on chromosome 18, or base pair 13,978 in the GenBank genomic region NC_000084 encoding TICAM2. The mutation, which is within the third and last exon, corresponds to residue 844 in the mRNA sequence NM_173394 and results in an aspartic acid (D) to valine (V) substitution at amino acid position 123 (D123V) of the protein. (J:215010)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ticam2 Mutation: 21 strains or lines available

References

• Original: J:215010 Zhang Z, et al., Mutagenetix entry for Branch. MGI Direct Data Submission. 2014
• All: 1 reference(s)