Tg(ACTA2-TFPI/CD4/SELP)#aAdor
Transgene Detail

Summary

• Symbol: Tg(ACTA2-TFPI/CD4/SELP)#aAdor
• Name: transgene insertion #a, Anthony Dorling
• MGI ID: MGI:5578126
• Synonyms: alpha-TFPI-Tg
• Transgene: Tg(ACTA2-TFPI/CD4/SELP)#aAdor Location: unknown
• Alliance: Tg(ACTA2-TFPI/CD4/SELP)#aAdor page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA2-TFPI/CD4/SELP)#aAdor expresses 3 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD4 (920)

  Cd4	(MGI:88335)

  Transgene codes for a fusion protein of human TFPI, CD4 and SELP.

  human

  SELP (6403)

  Selp	(MGI:98280)

  Transgene codes for a fusion protein of human TFPI, CD4 and SELP.

  human

  TFPI (7035)

  Tfpi	(MGI:1095418)

  Transgene codes for a fusion protein of human TFPI, CD4 and SELP.

• Mutation details: The human promoter drives expression of the fusion of human Tfpi, domains 3 and 4 of human CD4 domain and intracytoplasmic sequence of human SELP in smooth muscle cells. Four lines were generated. The unnamed line (#a) contains greater than 30 copies of the transgene. (J:135627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:135627 Chen D, et al., Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. J Thromb Haemost. 2006 Oct;4(10):2191-8
• All: 2 reference(s)